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Molecular chaperones: how cells stop proteins from misbehaving

Proteins are the action molecules of all cells, and to function properly, protein chains must fold and assemble correctly.


Proteins are the action molecules of all cells, and to function properly, protein chains must fold and assemble correctly. But each chain of every protein runs the risk that it will combine with one or more identical chains to form nonfunctional aggregates. Some protein aggregates are toxic to cells, such as neurones, and thus contribute to neurodegenerative and other human diseases. The probability of aggregation is increased by the highly crowded state of most intracellular compartments, but is reduced by the activities of a diverse group of proteins acting as ‘molecular chaperones’. Professor Ellis will present a historical and personal account of some of the key concepts and basic evidence.

Professor John Ellis studied botany and biochemistry at King`s College London. He moved in 1970 to the Department of Biological Sciences at the University of Warwick and retired as Emeritus Professor in 1996. John Ellis is the author of How Science Works: Evolution.

The 2011 Croonian Lecture has been awarded to Professor John Ellis FRS for his pioneering contributions to biochemistry, molecular cell biology and also plant sciences.

Admission free – no ticket or advance booking required. Doors open at 5.45pm and seats will be allocated on a first-come-first-served basis.

This event will be broadcast live on the web at royalsociety.org/live and available to view on demand within 48 hours of delivery.

Visit our video archive at royalsociety.tv


Speaker(s):

Professor John Ellis FRS | talks | www

 

Date and Time:

31 May 2011 at 6:30 pm

Duration:

1 hour

 

Venue:

The Royal Society
6-9 Carlton House Terrace
London
SW1Y 5AG
+44 20 74 51 2500
http://www.royalsociety.org

More at The Royal Society...

 

Tickets:

Free

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Additional Information:

Admission free – no ticket or advance booking required. Doors open at 5.45pm and seats will be allocated on a first-come-first-served basis.

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